Colon specific drug delivery of tramadol HCl for chronotherapeutics of arthritis

Oral Chronotherapeutics: Future of Drug Delivery Systems

Chronotherapeutics refers to a treatment method in which in vivo drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. it is also known as pulsatile drug delivery system and it focuses on the release of a drug at particular time and at a particular site in order to maintain constant blood levels of a particular drug. They are...

Colon Specific Drug Delivery of Tramadol Using Almond Gum in Vitro & in Vivo Evaluation

The aim of present work is to develop colon specific matrix tablets of tramadol using natural almond gum as carrier. Matrix tablets of Tramadol HCl were prepared by using 30, 40, 50, 60 and 70% w/w of tablets of Almond gum as carrier by wet granulation technique. These tablets were compression coated with Eudragit S100 to prevent drug release in stomach. All formulations were evaluated for hard...

role of polysaccharides in colon-specific drug delivery

Formulation and Evaluation of Chondroitin Sulphate Tablets of Aceclofenac for Colon Targeted Drug Delivery

   The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 ...

Formulation and Evaluation of Chondroitin Sulphate Tablets of Aceclofenac for Colon Targeted Drug Delivery

   The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 ...